Angiogenesis Foundation
News & MediaAnti-VEGF Agent Aflibercept Recommended in the European Union for Approval for Treatment of Macular Edema due to Branch and Central Retinal Vein Occlusion
Aflibercept (EYLEA®) Injection has been recommended for approval by the European Committee for Medicinal Products for Human Use (CHMP) for the treatment of visual impairment due to macular edema secondary to branch or central retinal vein occlusion (BRVO/CRVO). The...
The Angiogenesis Foundation Convenes the Canadian National Multistakeholder Expert Summit for Diabetic Macular Edema
Diabetes is the leading cause of blindness among adults aged 20-74. Patients with type 1 or type 2 diabetes are at risk for developing diabetic retinopathy, a debilitating eye disease, which can lead to the more severe condition of diabetic macular edema (DME). The...
Breakthrough Treatment for Chronic Wounds Gives Patients New Hope
For someone with diabetes, a stubbed toe, trivial scrape, or minor cut can rapidly become serious. This condition impairs the body’s healing ability, so a small wound can become life threatening. It is estimated that chronic wounds affect as many as 1 – 2% of people...
Antiangiogenic Agent Ramucirumab Gets FDA Approval for Treating Non-Small Cell Lung Cancer
The US Food and Drug Administration (FDA) expanded the indication of ramucirumab (Cyramza, Eli Lilly) to include the treatment of metastatic non-small cell lung cancer (NSCLC). Ramucirumab is a fully human monoclonal antibody that was developed for the treatment of...
Anti-VEGF Agent Ranibizumab Gets FDA Breakthrough Therapy Designation for Diabetic Retinopathy
The US Food and Drug Administration (FDA) has granted Lucentis (ranibizumab), a vascular endothelial growth factor (VEGF) inhibitor, its Breakthrough Therapy (BT) designation for the treatment of diabetic retinopathy. Diabetic retinopathy is a vision-threatening...
Anti-VEGF Agent Aflibercept Approved in Canada for Treating Diabetic Macular Edema (DME)
Health Canada recently approved anti-VEGF agent alibercept (Eylea) for the treatment of diabetic macular edema (DME). Eylea is also approved in Canada for the treatment of visual impairment due to macular edema secondary to central retinal vein occlusion (CRVO) and...
FDA Grants Priority Review of Antiangiogenic Agent Aflibercept for Treatment of Diabetic Retinopathy in DME Patients
The U.S. Food and Drug Administration (FDA) has accepted for priority review the supplemental biologics license application (sBLA) for EYLEA® (aflibercept) Injection for the treatment of diabetic retinopathy in patients with diabetic macular edema (DME). Under the...
Aflibercept injection shown to be superior to bevacizumab and ranibizumab in visual gains for DME patients
In the National Institutes of Health (NIH) sponsored, Diabetic Retinopathy Clinical Research Network (DRCR.net) comparative effectiveness study in patients with Diabetic Macular Edema (Protocol T), EYLEA® (aflibercept) Injection demonstrated a significantly greater...
Antiangiogenic agent bevacizumab gets FDA approval for treating platinum-resistant recurrent ovarian cancer
The U.S. Food and Drug Administration (FDA) approved antiangiogenic agent bevacizumab (Avastin®) in combination with chemotherapy for the treatment of women with platinum-resistant, recurrent ovarian cancer. The approval was based on results from the Phase III AURELIA...
The Angiogenesis Foundation Again Wins Highest Charity Rating
November 6, 2014: For the second consecutive year, the Angiogenesis Foundation has received the highest rating from Charity Navigator, the prominent independent evaluator of charities. Read More >
Patient Forum and Dinner, “Antiangiogenesis: Answer to Cancer”
On October 14, the Angiogenesis Foundation hosted a Patient Forum and Dinner, "Antiangiogenesis: Answer to Cancer," at the Westin Boston Waterfront Hotel, where it convened a diverse group of patients, scientists, caregivers, and healthcare practitioners to celebrate...
Anti-VEGF Agent Aflibercept FDA Approved for Treating Macular Edema Following Retinal Vein Occlusion (RVO)
The U.S. Food and Drug Administration (FDA) has approved EYLEA® (aflibercept) Injection for the treatment of Macular Edema following Retinal Vein Occlusion (RVO), which includes Macular Edema following Branch Retinal Vein Occlusion (BRVO) in addition to the...
Antiangiogenic Agent Aflibercept Approved in Japan for Treating Myopic Choroidal Neovascularization (CNV)
Bayer HealthCare's Japanese subsidiary, Bayer Yakuhin, Ltd. has received approval from the Japanese Ministry of Health, Labour and Welfare (MHLW) for EYLEA® (aflibercept) Injection for myopic choroidal neovascularization (myopic CNV). EYLEA has already been approved...
FDA Approves Bevacizumab Plus Chemotherapy for Cervical Cancer
The U.S. Food and Drug Administration, on August 14, 2014 approved bevacizumab solution for intravenous infusion (Avastin®, Genentech, Inc.) for the treatment of persistent, recurrent or metastatic cervical cancer, in combination with paclitaxel and cisplatin or...
Anti-VEGF agent aflibercept gets EU Approval for Treatment of Diabetic Macular Edema (DME)
Aflibercept (EYLEA) Injection has been approved by the European Commission for the treatment of visual impairment due to Diabetic Macular Edema (DME). Bayer Healthcare plans to launch EYLEA in DME in the EU this quarter. EYLEA was approved in the United States for the...
FDA approves anti-VEGF agent aflibercept for treating Diabetic Macular Edema (DME)
The U.S. Food and Drug Administration (FDA) has approved aflibercept (EYLEA®) Injection for the treatment of Diabetic Macular Edema (DME). The recommended dosage of EYLEA in patients with DME is 2 milligrams (mg) every two months (8 weeks) after five initial monthly...
FDA grants antiangiogenic agent bevacizumab priority review for cervical cancer
The U.S. Food and Drug Administration (FDA) has accepted a supplemental Biologics License Application (sBLA) from Genentech and granted Priority Review for antiangiogenic agent bevacizumab (Avastin®) plus chemotherapy for the treatment of women with persistent,...
Vascular endothelium found to play critical role in the brain’s regulation of blood flow
In a new study published online in the Journal of the American Heart Association June 12, 2014, researchers at Columbia Engineering report that they have identified a new component of the biological mechanism that controls blood flow in the brain. Led by Elizabeth M....
Anti-VEGF agent lenvatinib significantly improves progression-free survival in thyroid cancer patients
A new oral drug called lenvatinib looks promising as a treatment for a type of thyroid cancer that resists standard radiation, according to a later-stage clinical trial. "We are confident that, based on our findings, lenvatinib will eventually become a standard...
Antiangiogenic agent bevacizumab gets EU recommendation for treating platinum-resistant recurrent ovarian cancer
Bevacizumab (Avastin) becomes the first biologic medicine to be recommended for treating platinum-resistant recurrent ovarian cancer, the most challenging form of the disease to treat with only a quarter of patients surviving beyond five years. The CHMP's...
European commission recommends approval of anti-VEGF agent aflibercept for treatment of diabetic macular edema
Aflibercept (EYLEA®) injection has been recommended for approval by the European Committee for Medicinal Products for Human Use (CHMP) for the treatment of visual impairment due to diabetic macular edema (DME). The decision of the European Commission is expected in...
New antiangiogenic agent TAS-102 improves overall survival in patients with refractory mCRC
Treatment with the investigational oral agent TAS-102 significantly improved overall survival (OS) in a phase III trial for patients with heavily pretreated metastatic colorectal cancer (mCRC), prompting Taiho Oncology, the company developing the drug, to prepare a...
Ramucirumab is the first antiangiogenic agent to be approved for treatment of advanced stomach cancer
On April 21, 2014, the U. S. Food and Drug Administration approved ramucirumab (Cyramza) for use as a single agent for the treatment of patients with advanced or metastatic, gastric or gastroesophageal junction (GEJ) adenocarcinoma with disease progression on or after...
April 23, 2014: MarketWatch
April 23, 2014: The Bates-Jensen Wound Reach Foundation and the Angiogenesis Foundation announce Keith Brantly will run in the Wound Reach Foundation OUCH! Race. Read More >