Angiogenesis Foundation
News & MediaChemotherapy plus angiogenesis inhibitor shows effectiveness against advanced ovarian cancer
An important breakthrough for the treatment of ovarian cancer has been announced. A Phase III clinical trial has shown that adding the antiangiogenic agent bevacizumab (Avastin) to standard chemotherapy, and then continuing treatment with a maintenance dose of...
Angiogenesis inhibitors are safe despite elevated blood pressure risk, panel concludes
Cancer drugs that inhibit tumor blood vessel growth, called angiogenesis inhibitors, can be used effectively while minimizing elevated blood pressure (hypertensive) side effects if patients' blood pressure is closely monitored and controlled, a clinical panel has...
High-tech delivery of common spice into tumors holds promise for cancer prevention
Curcumin, a dietary polyphenol derived from the root of the plant Curcuma longa, has shown potential as a chemopreventive (cancer-preventing) substance, with beneficial effects affecting different stages of cancer development. Curcumin has an anti-tumor effect by...
Antiangiogenic agent Avastin shows promise for treating brain metastases in patients with advanced lung cancer
Brain metastases are a major cause of death in patients with advanced lung cancer. Avastin, a drug that interferes with the growth of tumor blood vessels (angiogenesis), is approved to treat both advanced non-small cell lung cancer (NSCLC) and a type of primary...
Antiangiogenic component of broccoli inhibits growth of breast cancer cells
Numerous scientific studies have shown the cancer protective effects of increasing intake of cruciferous vegetables, including broccoli, cauliflower, Brussels sprouts, kale and cabbage. Among the beneficial chemical components of these vegetables is sulforaphane, a...
Angiogenesis-stimulating hormone has potential as new treatment for major cause of hip replacements
Glucocorticoids are a class of steroids used to treat a wide array of chronic medical conditions, such as asthma, ulcerative colitis, and a number of rheumatologic disorders. Long-term use of glucocorticoids, however, causes bone loss and eventually can result...
Use of statins is associated with less recurrence in prostate cancer patients treated with radiation
Statins are cholesterol-lowering medications used by millions of people to lower their risk of heart disease and associated mortality. There has been growing interest in the potential anticancer activity of statins, based on preclinical studies showing that these...
Muscle cells surrounding blood vessels may initiate angiogenesis
A form of specialized muscle cells surrounding capillaries, called a pericyte, has been discovered to play a role in initiating angiogenesis, or blood vessel growth, according to researchers at Tufts University School of Medicine (TUSM) and the Massachusetts Institute...
Trial of Antiangiogenic Therapy Avastin Show Promise For the Treatment of Radiation Necrosis of the Central Nervous System
Patients undergoing radiation therapy for cancers of the central nervous system (CNS) or head and neck are at risk for a serious long-term side effect called radiation necrosis. This complication usually appears between a few months to more than a year after radiation...
Antiangiogenic Drug Sutent Shows Promise for Shrinking Kidney Tumors Prior to Kidney-Sparing Surgery
Kidney cancer patients often face difficult surgeries to remove or reduce the size of cancerous tumors, called nephron-sparing surgery (NSS). These patients often receive chemotherapy in an effort to shrink the tumor prior to NSS—called neoadjuvant therapy....
Drug Used to Treat Parasites May Have Tumor-Fighting, Antiangiogenic Properties
New research published in the online journal BMC Cancer indicates that a common anti-parasite medication suppresses two key growth factors involved in new blood vessel growth (angiogenesis) in cancerous tumors. The drug, albendazole, marketed as Albenza, Eskazole,...
A type of stem cell could treat stroke by promoting angiogenesis
In people who have suffered a stroke, blood flow must be restored to affected areas of the brain in order to minimize long-term effects, and death. Studies have shown that the infusion of a type of stem cell called mesenchymal stem cells (MSCs), derived from the bone...
Common anti-fungal medication has cancer-fighting properties
A drug commonly used to treat fungal infections has been found to have antiangiogenic properties, which could make it a good candidate for a cancer therapy. Researchers at Stanford University found that itraconazole (Sporanox), an agent used mainly to treat infections...
New role of immune system chemical in suppressing tumor blood vessel growth
Immune messenger chemicals in the body regulate the immune response by stimulating the production of growth factors or other chemical messengers to initiate or terminate an immune reaction. Interferons are used to treat several forms of cancer, although exactly how...
Scientists find angiogenic (blood vessel-building) genes in yeast
Researchers at the University of Texas at Austin have uncovered genes in yeast cells that humans may someday use to grow needed blood vessels. Even though yeasts lack any blood vessels, they use the same genes involved with blood vessels to repair their cell...
Angiogenesis at Symposium for Advanced Wound Care (SAWC)
William W. Li, M.D. and Vincent W. Li. M.D., M.B.A of the Angiogenesis Foundation will give presentations at the Symposium for Advanced Wound Care (SAWC) on Tuesday, April 20, at the Gaylord Palms Convention Center, in Kissimmee, Florida. Addressing leading...
Cinnamon Joins Growing Number of Herbs with Proven Antiangiogenic Activity
Cinnamon, the dry bark and twig of Cinnamomum spp., is one of the world’s most popular and oldest spices. Cinnamon extract has been found to possess potent antioxidant, antimicrobial, and antipyretic (fever reducing) properties. Several recent studies have found...
New mechanism explains how the body prevents formation of abnormal blood vessels
Researchers at Uppsala University, in collaboration with colleagues in Sweden, Norway, Finland, and Germany, have identified an entirely new mechanism by which the body inhibits the formation of abnormal new blood vessels. The discovery could lead to new treatments...
Blood vessel-building adult stem cells could treat a major cause of limb amputation
Researchers at Johns Hopkins have developed a new technique for delivering adult stem cells into the legs of patients to treat peripheral arterial disease, or PAD, a condition of poor circulation in the legs that affects about 10 million Americans. Left untreated, PAD...
New experimental approach using viruses destroys tumors by targeting their blood vessels in between pulses of antiangiogenic therapy
For several years, researchers have been working on a new approach to treating cancer, using viruses to infect and kill cancer cells while leaving normal cells unharmed. This approach, called oncolytic virotherapy, has the potential advantage of having low toxicity...
April 6, 2010 – Oprah Magazine
April 6, 2010: Oprah Magazine explains the connection between angiogenesis, cancer and diet. Read More >
Antiangiogenic Drug Avastin Saves Eyesight of Two Patients with a Rare Condition
A new report by British physicians published online in the journal Retinal Cases & Brief Reports used the antiangiogenic drug Avastin® (bevacizumab) to treat Sorsby Fundus Dystrophy (SFD), a genetic, early onset form of macular degeneration. It is apparently...
Antiangiogenic Cancer Treatment May Have New Uses for Treating Certain Infectious Diseases by Boosting Immune Response
New research published in the Journal of Clinical Investigation indicates that antiangiogenic drugs designed to fight cancer by blocking tumor blood supply could also augment treatment for a wide range of infectious diseases by boosting the body’s immune...
Blood Pressure Rise Predicts Survival in Kidney Cancer Patients Treated with the Antiangiogenic Drug Sutent
Elevated increased blood pressure (hypertension) is a common, treatable side effect of antiangiogenic cancer therapies. Now, new study findings in more than 500 patients indicate that development of hypertension may predict therapy response in patients with advanced...