Known Angiogenic Growth Factors
The lists below include some of the factors that have been shown to modulate angiogenesis:
Angiogenin
Angiopoietin-1
Del-1
Fibroblast growth factors: acidic (aFGF) and basic (bFGF)
Follistatin
Granulocyte colony-stimulating factor (G-CSF)
Hepatocyte growth factor (HGF) /scatter factor (SF)
Interleukin-8 (IL-8)
Leptin
Midkine
Placental growth factor
Platelet-derived endothelial cell growth factor (PD-ECGF)
Platelet-derived growth factor-BB (PDGF-BB)
Pleiotrophin (PTN)
Progranulin
Proliferin
Transforming growth factor-alpha (TGF-alpha)
Transforming growth factor-beta (TGF-beta)
Tumor necrosis factor-alpha (TNF-alpha)
Vascular endothelial growth factor (VEGF)/vascular permeability factor (VPF)
Known Angiogenesis Inhibitors
Angioarrestin
Angiostatin (plasminogen fragment)
Antiangiogenic antithrombin III
Arrestin
Chondromodulin
Canstatin
Cartilage-derived inhibitor (CDI)
CD59 complement fragment
Endostatin (collagen XVIII fragment)
Endorepellin
Fibronectin fragment
Fibronectin fragment (Anastellin)
Gro-beta
Heparinases
Heparin hexasaccharide fragment
Human chorionic gonadotropin (hCG)
Interferon alphagamma
Interferon inducible protein (IP-10)
Interleukin-12
Kringle 5 (plasminogen fragment)
Metalloproteinase inhibitors (TIMPs)
2-Methoxyestradiol
PEX
Pigment epithelium derived factor (PEDF)
Placental ribonuclease inhibitor
Plasminogen activator inhibitor
Platelet factor-4 (PF4)
Prolactin 16kD fragment
Proliferin-related protein (PRP)
Prothrombin kringle 2
Retinoids
Soluble Fms-like tyrosine kinase-1 (S-Flt-1)
Targeting fibronectin-binding integrins
Tetrahydrocortisol-S
Thrombospondin-1 (TSP-1) and -2
Transforming growth factor-beta (TGF-b)
Troponin I
Tumstatin
Vasculostatin
Vasostatin (calreticulin fragment)
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