Angiogenesis Foundation
News & MediaAntiangiogenic Drug Effective for Treating a Leading Cause of Vision Loss in People with Diabetes
Results announced from a late stage (phase 3) clinical trial showed that the angiogenesis inhibitor Lucentis® (ranibizumab injection) improves vision in people with diabetic macular edema (DME), a leading cause of vision loss in people with diabetes. DME is a...
Pain Reliever Celecoxib (Celebrex) Protects Against Common Forms of Skin Cancer in New Study
A study published in the Journal of the National Cancer Institute (Dec. 15, 2010) shows that the commonly prescribed pain medication celecoxib (Celebrex) significantly reduces the incidence of non-melanoma skin cancers in people at high risk for these tumors. ...
Antiangiogenic Eye Drug Shows Positive Results For Treating Leading Cause of Vision Loss in the Elderly in Two Late-stage Clinical Trials
Age-related macular degeneration (AMD) is the leading cause of blindness in the elderly. The underlying cause in most cases is the abnormal growth of leaky blood vessels beneath the retina, the nerve layer that processes light. The current standard of care...
Angiogenesis inhibitor found effective for treating brain tumors in children with genetic disease; accelerated FDA approval follows study results
The U.S. Food and Drug Administration (FDA) has approved a type of antiangiogenic drug called an mTOR inhibitor to treat a brain tumor disorder related to tuberous sclerosis, a genetic disorder that affects approximately 1 in 6,000 infants and children. Tuberous...
DPE, a Polyphenol in Olive Oil Inhibits Angiogenesis in Colon Cancer
Olive oil, along with red wine and berries, contains polyphenols, which have been shown to suppress inflammation, angiogenesis and tumor growth. In a new study, researchers describe how one type of polyphenol found in olive oil inhibits angiogenesis in a mouse model...
Celecoxib Combined with Fish Oil Suppresses Early Stage Murine Breast Cancer
A new study in the journal Tumor Biology has found that a combination of fish oil and celecoxib, a COX-2 inhibitor, is more effective in suppressing the development of breast cancer than either substance alone. In the study, the combination of fish oil and celecoxib...
Protein that boosts the creation of tumor blood vessels portends poor survival in ovarian cancer
A protein associated with cancer progression made by tumors also unexpectedly regulates the creation of new blood vessels (angiogenesis) that feed the tumor. The new findings come from scientists at The University of Texas MD Anderson Cancer Center and were reported...
Old antibiotic reduces the growth of harmful blood vessels following stroke
A daily dose of an old antibiotic may help people with diabetes avoid a stroke, or at least minimize its damage, according to a new study by researchers at the Medical College of Georgia that was recently reported in the Journal of Cerebral Blood Flow and Metabolism....
Scientists reveal new target for anti-angiogenesis drugs
A new study describes how a carbohydrate-binding protein, galectin-3, promotes angiogenesis, the growth of new blood vessels. Targeting the protein, scientists identified two approaches that significantly reduced angiogenesis in mice. These discoveries, published...
Scientists find gas pedal and brake for uncontrolled blood vessel growth
Researchers at the University of California, San Diego School of Medicine (UCSD) have identified a new way to regulate the uncontrolled growth of blood vessels, known as angiogenesis, an underlying mechanism in a broad range of diseases and conditions. David A....
Cocoa flavanols protect the heart by promoting new blood vessel growth, study shows
A new study by cardiologists and researchers at UCSF found that high concentrations of cocoa flavanols—natural compounds found in apples, grapes, tea, cocoa and cherries—decrease blood pressure and improve the health of blood vessels in patients with heart...
Antiangiogenic ingredient in red wine may prevent some blinding diseases
Research conducted at the Washington University School of Medicine in St. Louis indicates that resveratrol, a naturally occurring compound found in red wine, grapes, blueberries, peanuts, and other plants, inhibits the abnormal growth of new blood vessels, or...
FDA approves antiangiogenic therapy for a leading cause cause of blindness in the elderly
The U.S. Food and Drug Administration (FDA) has approved Lucentis (ranibizumab injection) for the treatment of a condition called macular edema that occurs after another blinding condition known as retinal vein occlusion (RVO). RVO is a leading cause of blindness in...
Immune cells play role in new blood vessel growth after heart attacks
A research team from McGill University in Montreal, Canada, reported that heart function in mice was preserved when monocytes—a type of infection-fighting white blood cell produced in the bone marrow—were implanted following a heart attack. Monocytes also...
Bee venom inhibits angiogenesis, suppresses lung cancer growth
The venom of the European honeybee is used for treating various diseases in Oriental medicine. In a recent paper published in the online journal Cancer Letters, Korean researchers investigated the potency of bee venom as an inhibitor of new blood vessel growth...
Drug that restricts blood supply to prostate tumors delays disease progression
A blood vessel-blocking drug called tasquinimod slowed the rate of disease progression in a clinical trial of 200 prostate cancer patients, according to experts at Johns Hopkins, Roswell Park Cancer Institute, and Duke University. Tasquinimod is an "anti-angiogenesis"...
Chemotherapy plus angiogenesis inhibitor shows effectiveness against advanced ovarian cancer
An important breakthrough for the treatment of ovarian cancer has been announced. A Phase III clinical trial has shown that adding the antiangiogenic agent bevacizumab (Avastin) to standard chemotherapy, and then continuing treatment with a maintenance dose of...
Angiogenesis inhibitors are safe despite elevated blood pressure risk, panel concludes
Cancer drugs that inhibit tumor blood vessel growth, called angiogenesis inhibitors, can be used effectively while minimizing elevated blood pressure (hypertensive) side effects if patients' blood pressure is closely monitored and controlled, a clinical panel has...
High-tech delivery of common spice into tumors holds promise for cancer prevention
Curcumin, a dietary polyphenol derived from the root of the plant Curcuma longa, has shown potential as a chemopreventive (cancer-preventing) substance, with beneficial effects affecting different stages of cancer development. Curcumin has an anti-tumor effect by...
Antiangiogenic agent Avastin shows promise for treating brain metastases in patients with advanced lung cancer
Brain metastases are a major cause of death in patients with advanced lung cancer. Avastin, a drug that interferes with the growth of tumor blood vessels (angiogenesis), is approved to treat both advanced non-small cell lung cancer (NSCLC) and a type of primary...
Antiangiogenic component of broccoli inhibits growth of breast cancer cells
Numerous scientific studies have shown the cancer protective effects of increasing intake of cruciferous vegetables, including broccoli, cauliflower, Brussels sprouts, kale and cabbage. Among the beneficial chemical components of these vegetables is sulforaphane, a...
Angiogenesis-stimulating hormone has potential as new treatment for major cause of hip replacements
Glucocorticoids are a class of steroids used to treat a wide array of chronic medical conditions, such as asthma, ulcerative colitis, and a number of rheumatologic disorders. Long-term use of glucocorticoids, however, causes bone loss and eventually can result...
Use of statins is associated with less recurrence in prostate cancer patients treated with radiation
Statins are cholesterol-lowering medications used by millions of people to lower their risk of heart disease and associated mortality. There has been growing interest in the potential anticancer activity of statins, based on preclinical studies showing that these...
Muscle cells surrounding blood vessels may initiate angiogenesis
A form of specialized muscle cells surrounding capillaries, called a pericyte, has been discovered to play a role in initiating angiogenesis, or blood vessel growth, according to researchers at Tufts University School of Medicine (TUSM) and the Massachusetts Institute...