Therapeutic angiogenesis modalities represent a broad range of interventions that generate new blood vessel growth to promote neovascularization and tissue repair. Presently, there are three major indications for which angiogenic therapies are in clinical use:
1) chronic wounds (e.g. diabetic lower extremity ulcers, venous leg ulcerations, pressure ulcers, arterial ulcers);
2) peripheral arterial disease; and
3) ischemic heart disease.
In such conditions, the therapeutic goal is to stimulate angiogenesis to improve perfusion, deliver survival factors to sites of tissue repair, mobilize regenerative stem cell populations, and ultimately, restore form and function to the tissue.
For a list of anti-angiogenic agents please check our Treatments page.